Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9894474 | Regulatory Peptides | 2005 | 7 Pages |
Abstract
Prolactin-releasing peptide (PrRP) was first isolated from bovine hypothalamus as an orphan G-protein-coupled receptor using the strategy of reverse pharmacology. The initial studies showed that PrRP was a potent and specific prolactin-releasing factor. Morphological and physiological studies, however, indicated that PrRP may play a wide range of roles in neuroendocrinology other than prolactin release, i.e., metabolic homeostasis, stress responses, cardiovascular regulation, gonadotropin secretion, GH secretion and sleep regulation. This review will provide the current knowledge of PrRP, especially its roles in energy metabolism and stress responses.
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Authors
Binggui Sun, Ken Fujiwara, Sachika Adachi, Kinji Inoue,