Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9894541 | Regulatory Peptides | 2005 | 8 Pages |
Abstract
In conclusion, ANF stimulates DA uptake by kidney tubular cells. ANF effects are mediated by NPR-A receptors coupled to guanylate cyclase and cGMP as second messenger. The process involved was characterized as a typical extraneuronal uptake, and characterized as temperature- and sodium-dependent. This mechanism could be related to DA effects on sodium reabsorption and linked to ANF enhanced natriuresis in the kidney. The increment of endogenous DA into tubular cells, as a consequence of increased DA uptake, would permit D1 receptor recruitment and Na+,K+-ATPase activity inhibition, which results in decreased sodium reabsorption and increased natriuresis.
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Authors
Belisario E. Fernández, Alicia H. Correa, Marcelo R. Choi,