Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9894549 | Regulatory Peptides | 2005 | 7 Pages |
Abstract
The present data directly demonstrate the presence of both PPT-A mRNA and tachykinin immunoreactivity in inflammatory airway cells which are in direct contact to NK-1 receptor positive glandular myoepithelium. Our findings indicate that besides neurally released tachykinins, also inflammatory cell-derived tachykinins may lead to glandular secretion via NK-1 receptor stimulation. This points to a major second source of these proinflammatory mediators in chronic inflammatory airway diseases such as COPD or asthma.
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Authors
Jochen Springer, David A. Groneberg, Reinhard Pregla, Axel Fischer,