Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9894551 | Regulatory Peptides | 2005 | 6 Pages |
Abstract
Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 μg) or orexin B (10, 30, or 100 μg). When compared to vehicle injections, the 10 and 20 μg doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 μg orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jon J. Ramsey, Joseph W. Kemnitz, Wendy Newton, Kevork Hagopian, Terrell A. Patterson, Andrew G. Swick,