| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9917689 | European Journal of Pharmaceutical Sciences | 2005 | 10 Pages |
Abstract
Hb release from microspheres showed a pH-dependent profile and was affected by chitosan coating. Under simulated gastric conditions, a total Hb burst release from uncoated microspheres was decreased with one-stage and two-stage chitosan coatings (68% and 28%, respectively). At pH 6.8, the Hb release from coated microspheres was fast but incomplete. These results suggest an optimization of the coating method to protect Hb under acidic conditions and to permit a complete but sustained release of Hb.
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Authors
António J. Ribeiro, Catarina Silva, Domingos Ferreira, Francisco Veiga,