Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9917743 | European Journal of Pharmaceutical Sciences | 2005 | 5 Pages |
Abstract
We investigated the superoxide anion-scavenging effects of six selenocarbamates and four thiocarbamates, using a highly sensitive quantitative chemiluminescence method. At 333Â nM, six selenocarbamates and four thiocarbamates scavenged in the range of 2.9-68.7% of O2â. Se-methyl N-phenylselenocarbamate and Se-methyl N-(4-methylphenyl)selenocarbamate exhibited the strongest superoxide anion-scavenging activity among the Se-selenocarbamates. In contrast, the corresponding S-thiocarbamates had moderate inhibitory effect. The 50% inhibitory concentrations (IC50) of Se-methyl-N-phenylselenocarbamate and Se-methyl-N-(4-methylphenyl)selenocarbamate were determined to be 140Â nM and 162Â nM, respectively. Thus, these compounds acted in vitro as effective and potentially useful O2â scavengers.
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Authors
Hitoe Takahashi, Atsuyoshi Nishina, Ryo-hei Fukumoto, Hirokazu Kimura, Mamoru Koketsu, Hideharu Ishihara,