Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918562 | International Journal of Pharmaceutics | 2005 | 4 Pages |
Abstract
Latanoprost in water is not stable against heat stress due to hydrolysis of the isopropyl ester in the latanoprost molecule. Therefore, the storage condition of latanoprost ophthalmic solution, Xalatan® brand, was in a low temperature (2-8 °C). We formulated a favorable ophthalmic lipid emulsion of latanoprost using polyvinyl alcohol as emulsifier which showed a good heat stability. The assays of the latanoprost ophthalmic lipid emulsions adjusted to pH 5.0, 6.0 and 7.0 were 100.4%, 100.7% and 99.2% after storage for 4 weeks at 60 °C, respectively. The possibility of room temperature storage for the latanoprost ophthalmic lipid emulsion was demonstrated.
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Authors
Yusuke Sakai, Shin-Ichi Yasueda, Akira Ohtori,