Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918576 | International Journal of Pharmaceutics | 2005 | 11 Pages |
Abstract
The formulations were screened in vitro according to their dissolution characteristics. The drug release from each preparation was analyzed using release kinetics theories. In Tablet A, the value of the exponent(n) representing the apparent diffusion mechanism determined from the Korsmeyer-Peppas model equation was about 0.6 and was unlikely to be affected by the rotation speed. In Tablet B, the value of the exponent(n) by the Korsmeyer-Peppas model equation changed with the paddle rotation speed. These results suggested that the drug release mechanism of Tablet B is greatly affected by the extent of physical force in the gastrointestinal tract.
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Authors
Tetsuo Hayashi, Hideyoshi Kanbe, Minoru Okada, Makoto Suzuki, Yasuo Ikeda, Yoichi Onuki, Tetsuo Kaneko, Takashi Sonobe,