Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918644 | International Journal of Pharmaceutics | 2005 | 9 Pages |
Abstract
Adding magnesium and calcium salts, the intrinsic dissolution rate of EuSNa decreased of at least 25%. Mucoadhesive tablets were prepared with the most suitable blends and tested on human healthy volunteers. The addition of the magnesium and calcium increased the in vivo permanence time without affecting the mucoadhesive performances. The lack of swelling, mucosal irritation and unpleasant sensation allow the use of such blends in the preparation of mucoadhesive tablets.
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Authors
Francesco Cilurzo, Francesca Selmin, Paola Minghetti, Luisa Montanari,