| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9918752 | International Journal of Pharmaceutics | 2005 | 14 Pages |
Abstract
Triblock copolymer PLA-PEG-PLA were synthesized using ring opening polymerization with different LA/EG ratio. Micellar aggregates were prepared from these block copolymers and characterized. The degradation characteristics of selected copolymers were assessed in both micellar and film forms. Surface segregation of PEG was also quantified as a function of copolymer composition. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanospheres with good efficiency. The drug release profile showed good control over the release of paclitaxel from these polymers.
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Authors
Subbu S. Venkatraman, Pan Jie, Feng Min, Boey Yin Chiang Freddy, Gan Leong-Huat,