| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9918759 | International Journal of Pharmaceutics | 2005 | 8 Pages |
Abstract
The bioavailibility of diltiazem in the rabbits pretreated with quercetin is increased significantly compared with the control, but not in the rabbits co-administered with quercetin. The increased bioavailability of diltiazem in the rabbits pretreated with quercetin might have been resulted result from the quercetin, which inhibits the efflux pump P-glycoprotein and the first-pass metabolizing enzyme CYP 3A4.
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Authors
Jun-Shik Choi, Xiuguo Li,