Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918813 | International Journal of Pharmaceutics | 2005 | 9 Pages |
Abstract
Hydrotalcite is a biocompatible lamellar anionic clay formed by double hydroxide layers with a metal cation coordinating four OH groups. The different layers are held together by anionic hosts that can be replaced by a simple ion-exchange process. The synthetic Mg-Al-hydrotalcite was used to intercalate ferulic acid, a compound that shows antioxidant properties due to its free radical scavenger capacity. Analysis of the intercalated compound showed a good intercalation percentage (35.53%) accompanied by an increase of the interlayer space from 7.8Â Ã
(chloride form) to 17.1Â Ã
due to the presence of the ferulate. The intercalation product was stable in water, did not show any significant degradation after UV-irradiation, had a higher capacity of UV absorption in comparison to both the pure ferulic acid and ferulic acid-hydrotalcite chloride physical mixture. The intercalated compound was formulated in a siliconic cream and the ferulate in vitro release profiles determined.
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Authors
C. Rossi, A. Schoubben, M. Ricci, L. Perioli, V. Ambrogi, L. Latterini, G.G. Aloisi, A. Rossi,