| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9918817 | International Journal of Pharmaceutics | 2005 | 7 Pages |
Abstract
Results showed that praziquantel was absorbed by passive diffusion. The apparent permeability constant value was 4.4Â ÃÂ 10â5Â cm/s. Binding was not influenced by the addition of highly bound drugs. Dissolution from a tablet formulation showed that the rate of praziquantel was dependent on the components of the media. Although the simulated media could explain the influence of the lipids on praziquantel absorption, they were not able to forecast the influence of carbohydrates. Further refinements are required to explain the in vivo data.
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Authors
González-Esquivel Dinora, Rivera Julio, Castro Nelly, Yepez-Mulia Lilian, Helgi Jung Cook,