| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9918854 | International Journal of Pharmaceutics | 2005 | 8 Pages |
Abstract
The experimental octanol/water partition coefficient data, of 108 compounds from the data set [Rytting, E., Lentz, K.A., Chen, X., Qian, F., Venkatesh, S., 2004. A quantitative structure-property relationship for predicting drug solubility in PEG 400/water cosolvent systems. Pharm. Res. 21, 237-244] was compared to calculated values using the computer programs ClogP®, ACD/logPdb® and KowWin®. It was found that all the three programs have a user friendly interface but ClogP® appears to be the more accurate predictor of log Kow.
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Authors
Stephen G. Machatha, Samuel H. Yalkowsky,