Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918931 | International Journal of Pharmaceutics | 2005 | 11 Pages |
Abstract
Such an approach, applied to the development of a self-emulsifying system for nimesulide as poorly water-soluble model drug, resulted in different formulations with improved drug solubility and permeability characteristics. The data demonstrate that pellets composed of oil to surfactant ratio of 1:4 (w/w) presented improvement in performance in permeation experiments.
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Authors
Erica Franceschinis, Dario Voinovich, Mario Grassi, Beatrice Perissutti, Jelena Filipovic-Grcic, Anita Martinac, Francesco Meriani-Merlo,