Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918933 | International Journal of Pharmaceutics | 2005 | 6 Pages |
Abstract
The nanoemulsified composite (NECâ¢) delivery system is a patented technology based on the incorporation of a double microemulsion into microporous carrier. This approach was applied on the very water insoluble ubidecarenone drug. The resulting composite powder showed good technological properties such as flowability; also good stability was evidentiated, with size of the nano-droplets released from the systems maintained equal to the starting size also after a long storage. Furthermore very good biopharmaceutical properties were originated, with water solubility concentrations up to 50-fold higher than pure ubidecarenone and oral absorption in rats up to three-fold greater than standard commercial products in terms of plasma levels and AUC.
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
F. Carli, E.E. Chiellini, B. Bellich, S. Macchiavelli, G. Cadelli,