Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918937 | International Journal of Pharmaceutics | 2005 | 5 Pages |
Abstract
Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150Â nm and presented about 15Â wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.
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Authors
Marjan Bele, ÄorÄe DmitraÅ¡inoviÄ, Odon PlaninÅ¡ek, Mateja Salobir, Stane SrÄiÄ, Miran GaberÅ¡Äek, Janko Jamnik,