Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918944 | International Journal of Pharmaceutics | 2005 | 9 Pages |
Abstract
By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.
Keywords
DMFpoly[α,β-(N-2-hydroxyethyl-dl-aspartamide)]PolyaspartamidePHEASNFEDACTWADTNBDTTTGADSC1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochlorideN,N′-dimethylformamideThioglycolic acidThermogravimetryThiomerdithiothreitolMicroparticlesAtomic spectrometrySEMMucoadhesionScanning electron microscopyDifferential scanning calorimetry
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Authors
M. Bubenik BiliÄiÄ, J. FilipoviÄ-GrÄiÄ, A. Martinac, M. BarbariÄ, B. Zorc, B. Cetina-Äižmek, P. Tudja,