| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9918961 | International Journal of Pharmaceutics | 2005 | 8 Pages |
Abstract
Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticulate drug carriers made of poly(d,l-lactide-co-glycolide) acid with controlled size were designed. Praziquantel, a hydrophobic molecule, was entrapped into the nanoparticles with theoretical loading varying from 10 to 30% (w/w). This study investigates the effects of some process variables on the size distribution of nanoparticles prepared by emulsion-solvent evaporation method. The results show that sonication time, PLGA and drug amounts, PVA concentration, ratio between aqueous and organic phases, and the method of solvent evaporation have a significant influence on size distribution of the nanoparticles.
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Authors
Rubiana M. Mainardes, Raul C. Evangelista,