Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9918979 | International Journal of Pharmaceutics | 2005 | 8 Pages |
Abstract
Results demonstrate that a high portion of the dose administered is rapidly excreted; since 1-h post-injection only about 30% of the dose administered was detected cumulatively in the animal tissues. After this the elimination of arsenic was a slow process with a total body elimination rate constant of 0.023 hâ1, corresponding to a half-life of 30 h. Tissues with the highest arsenic concentration during the study period are: spleen-kidneys-stomach, followed by lung, liver, intestines-heart, carcass + skin and finally blood. No acute toxicity, or effect on the body or organ weight of the mice was observed.
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Authors
Sophia G. Antimisiaris, Pavlos Klepetsanis, Venetia Zachariou, Eleftheria Giannopoulou, Panagiotis V. Ioannou,