In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb-c mice

Results demonstrate that a high portion of the dose administered is rapidly excreted; since 1-h post-injection only about 30% of the dose administered was detected cumulatively in the animal tissues. After this the elimination of arsenic was a slow process with a total body elimination rate constant of 0.023 h−1, corresponding to a half-life of 30 h. Tissues with the highest arsenic concentration during the study period are: spleen-kidneys-stomach, followed by lung, liver, intestines-heart, carcass + skin and finally blood. No acute toxicity, or effect on the body or organ weight of the mice was observed.