| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9940682 | American Journal of Hypertension | 2005 | 8 Pages |
Abstract
Increased baromechanical stress is not a requisite for accumulation of T cells and macrophages in the kidney in the coarctation-induced HTN and possibly in other hypertensive disorders. On the contrary, renal hypoperfusion and the consequent activation of renin-angiotensin system may mediate this process by promoting local induction of chemoattractant and inflammatory cytokines. The observed tubulointerstitial inflammation in this model is associated with leukocyte activation in the systemic circulation.
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Authors
Bernardo Rodriguez-Iturbe, Yasmir Quiroz, Choong H. Kim, Nosratola D. Vaziri,