Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9940727 | American Journal of Hypertension | 2005 | 6 Pages |
Abstract
Reduced p115RhoGEF may explain the downregulation of RhoA/ROK pathway in BS/GS. This is the first report of upstream regulators of RhoA level in BS/GS, a human clinical condition characterized by reduced vascular tone regulation. Because BS/GS represent the mirror image of derangements involved in hypertension, the reduced RhoGEF expression in BS/GS underlines a major impact of RhoA/ROK pathway on blood pressure regulation and confirms BS/GS as a good human model for exploring mechanisms involved in the pathophysiology of hypertension and remodeling.
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Authors
Elisa Pagnin, Andrea Semplicini, Michelangelo Sartori, Achille C. Pessina, Lorenzo A. Calò,