| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9940756 | American Journal of Hypertension | 2005 | 7 Pages |
Abstract
More than 90% of adrenal Ang II originates at adrenal tissue sites. Local adrenal Ang II generation occurs extracellularly and is followed by internalization via AT1 receptor-mediated endocytosis. Enhanced angiotensin generation, combined with incomplete AT1 receptor blockade and the large adrenal AT1 receptor reserve, explains why eprosartan increased rather than decreased adrenal Ang II. Our data do not support angiotensin generation by truncated prorenin.
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Authors
Jorge P. van Kats, Wenxia Chai, Dirk J. Duncker, Maarten A.D.H. Schalekamp, A.H. Jan Danser,