β2-Adrenoceptor Polymorphisms Relate to Insulin Resistance and Sympathetic Overactivity as Early Markers of Metabolic Disease in Nonobese, Normotensive Individuals

The Gly16 mutation of the β2-adrenoceptor gene is associated with increased insulin resistance, adiposity, and BP accompanied by higher plasma NE levels early in the metabolic disease in developing obesity. These findings show an important role of β2-adrenoceptor gene polymorphisms in the association of insulin resistance in hypertension and obesity.