Antioxidant Enzymes and Effects of Tempol on the Development of Hypertension Induced by Nitric Oxide Inhibition

We conclude that L-NAME-induced hypertension is associated with an upregulation of antioxidant SOD, GPX, and GR activities. Moreover, the results indicate that tempol attenuates hypertension on nitric oxide-deficient rats and that oxidative stress participates in the established phase of this type of hypertension.