Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice

Article ID	Journal	Published Year	Pages	File Type
9954251	Regenerative Therapy	2018	13 Pages	PDF

Abstract

The single compound IC-2 induced hepatic cell sheets that possess potent regeneration capacity and ameliorate acute liver injury.

Keywords

TGFα GRx ALT CCl4 8-OHdG α1-antitrypsin ChREBP EGFR IL-1RA CBP PRX LXR C5aR STAT-3 HB-EGF Trx TrxR Ceruloplasmin RBP4 AREG ERK HGFR A1AT NF-κB TNFα IL-6 Transferrin PCNA GSH C4a GPX BM-MSCs MDA 8-hydroxydeoxyguanosine DMSO AST Aspartate aminotransferase Alanine aminotransferase amphiregulin interleukin-1 receptor antagonist Proliferating Cell Nuclear Antigen Apoe apolipoprotein E interleukin-6 Liver regeneration transforming growth factor alpha thioredoxin reductase tumor necrosis factor alpha Complement C3 thioredoxin Dimethyl sulfoxide SOD Mesenchymal stem cells Bone marrow-derived mesenchymal stem cells Superoxide dismutase Nuclear factor-kappa B malondialdehyde Acute liver failure CREB-binding protein Retinol binding protein 4 Peroxiredoxin liver X receptor Carbon tetrachloride carbohydrate-responsive element-binding protein extracellular signal-regulated kinase Glutathione glutathione reductase glutathione peroxidase Glutaredoxin hepatocyte growth factor receptor Epidermal growth factor receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice

Authors

Noriko Itaba, Ikuya Noda, Hiroyuki Oka, Yohei Kono, Kaori Okinaka, Tsuyoshi Yokobata, Shizuma Okazaki, Minoru Morimoto, Goshi Shiota,