Suppression of Endothelial Progenitor Cells in Human Coronary Artery Disease by the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine

Article ID	Journal	Published Year	Pages	File Type
9959470	Journal of the American College of Cardiology	2005	9 Pages	PDF

Abstract

Asymmetric dimethylarginine is an endogenous inhibitor of mobilization, differentiation, and function of EPCs. This contributes to the cardiovascular risk in patients with high ADMA levels and may explain low numbers and function of EPCs in patients with coronary artery disease.

Keywords

3-hydroxy-3-methyl-glutaryl coenzyme A ADMA CFU Dil-Ac-LDL PBMC EPC FITC HMG-CoA eNOS coronary artery disease asymmetric dimethylarginine peripheral blood mononuclear cells Endothelial progenitor cell endothelial nitric oxide synthase CAD fluorescein isothiocyanate Nitric oxide colony forming unit

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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Suppression of Endothelial Progenitor Cells in Human Coronary Artery Disease by the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine

Authors

Thomas MD, Dimitrios PhD, Sylvia Stein, Maximilian Schultheiss, Martin MD, Stefan D. MD, PhD, Philip A. (FRCP), Georg MD, Johann MD,