Targeted Inhibition of Î²-Adrenergic Receptor Kinase-1-Associated Phosphoinositide-3 Kinase Activity Preserves Î²-Adrenergic Receptor Signaling and Prolongs Survival in Heart Failure Induced by Calsequestrin Overexpression

Article ID	Journal	Published Year	Pages	File Type
9960273	Journal of the American College of Cardiology	2005	9 Pages	PDF

Abstract

These data in the CSQ model of cardiac dysfunction indicate that membrane-targeted PI3K activity plays a detrimental role in heart failure, and its inhibition represents a novel therapeutic approach to ameliorate cardiac dysfunction and improve survival.

Keywords

PI3K percent fractional shortening %FS CSQ βAR GSK PKB cAMP MAPKs Cyclic adenosine monophosphate ISO isoproterenol phosphoinositide-3 kinase wild type protein kinase B Calsequestrin mitogen-activated protein kinases Glycogen synthase kinase 3β β-Adrenergic receptor