Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9987990 | Alzheimer's & Dementia: Translational Research & Clinical Interventions | 2018 | 15 Pages |
Abstract
This study demonstrates that in early PD, resting-state fMRI networks show spatial and temporal differences of fMRI signal characteristics. However, the default mode network was not associated with any measurable changes. Furthermore, by incorporating an optimum window size in a dynamic functional connectivity analysis, we found altered whole-brain temporal features in early PD, showing that PD subjects spend significantly more time than healthy controls in a specific brain state. These findings may help in improving diagnosis of early never-medicated PD patients. These key observations emerged in a Center for Biomedical Research Excellence-supported research environment.
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Authors
Dietmar Cordes, Xiaowei Zhuang, Muhammad Kaleem, Karthik Sreenivasan, Zhengshi Yang, Virendra Mishra, Sarah J. Banks, Brent Bluett, Jeffrey L. Cummings,