Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9998 | Biomaterials | 2007 | 8 Pages |
Abstract
The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τwτw, the threshold RthRth and optimal RoptRopt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell–particle interface. It is shown that the contribution of F is as important as that of C and GG. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
P. Decuzzi, M. Ferrari,