Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10137174 | Stem Cell Research | 2018 | 4 Pages |
Abstract
Duchenne muscular dystrophy (DMD) is a common X-linked recessive disorder for which there is no present cure. In this paper, we reported the generation of ZZUi008-A, an induced pluripotent stem cell(iPSC) line derived from chorionic villus(CV) cells of a fetus with a deletion mutation in exon 33 of the dystrophin gene (DMD). The cell line was generated using feeder-free and virus-free conditions, and the established cell line retains the original DMD mutation, a normal karyotype, expresses pluripotency markers, able to differentiate into three lineages. This ZZUi008-A cell line could provide a promising tool to study this complex disease.
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Authors
Xiaofan Zhu, Aojie Cai, Jingjing Meng, Lina Liu, Siying Cui, Suzhen Qu, Junhong Zhao, Ning Liu, Xiangdong Kong,