Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162641 | Journal of Pharmaceutical Sciences | 2014 | 9 Pages |
Abstract
Approximately 30% of active pharmaceutical ingredients (APIs) experience agglomeration, granulation, and breakage during agitated drying. Currently, there is no small-scale bench tool to help assess and observe granulation behavior of APIs in the laboratory and subsequently lead to the development of a robust drying method. As a result, more conservative drying methods are usually used at scale and much longer drying times are needed. In this work, we build on work reported in the literature and demonstrate that a mixer torque rheometer (MTR) can be a useful small-scale tool to flag potentially problematic granulation behavior of APIs under different conditions. The results from the MTR were confirmed using a second new tool involving the use of an acoustic mixer to verify and observe the granulation behavior on a small scale. We also show consistency between the data collected at the laboratory and the pilot plant scales. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:152-160, 2014
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Siyan Zhang, David J. Lamberto,