Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10520551 | Transfusion Clinique et Biologique | 2013 | 4 Pages |
Abstract
Erythropoiesis is finely regulated by two major cytokines, stem cell factor (SCF) and erythropoietin (Epo). Decrease levels of Epo result in caspase activation and erythroid progenitors apoptosis. However, normal erythroid cell maturation requests caspase activation and cleavage of various caspase substrates, except the erythroid transcription factor GATA-1, that is protected by interaction with the chaperone HSP70Â in the nucleus. Therefore, molecular abnormalities associated with decrease of HSP70Â expression in the nucleus may result in ineffective erythropoiesis characterized by apoptosis and impaired maturation of erythroid precursors. These findings open new potential targeted therapies for erythroid disorders.
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Authors
O. Hermine, J.-B. Arlet, J.-A. Ribeil, F. Guillerm, J. Vandekerkhove, G. Courtois,