| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586215 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
A series of caffeic acid amides 3-13 were designed and synthesized through scaffold hopping from berbeine and 2, and their synergistic activity with fluconazole against fluconazole-resistant Candida albicans was evaluated in vitro. The title caffeic acid amides 3-30 except 26 exhibited potent activity. The SAR study indicates that the dihydroxyl groups and the amido group in the caffeic acid amides are the important pharmacophores.
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Authors
Li Dai, Chengxu Zang, Shujuan Tian, Wei Liu, Shanlun Tan, Zhan Cai, Tingjunhong Ni, Maomao An, Ran Li, Yue Gao, Dazhi Zhang, Yuanying Jiang,