Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10586259 | Bioorganic & Medicinal Chemistry Letters | 2015 | 8 Pages |
Abstract
Two substituted biaryl analogues of colchicine and combretastatin A4, readily available through a one-step, protecting group free Suzuki-Miyaura reaction were discovered to exhibit anticancer activity while simultaneously being of low cytotoxicity to noncancerous cell lines. The compounds were shown to initiate apoptosis selectively via a mechanism involving inhibition of tubulin polymerization.
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Authors
James McNulty, Sean van den Berg, Dennis Ma, Daniel Tarade, Seema Joshi, Julia Church, Siyaram Pandey,