| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586260 | Bioorganic & Medicinal Chemistry Letters | 2015 | 6 Pages |
Abstract
We report here a new series of prodrugs of paclitaxel containing self-immolative disulfide linkers with improved water-solubility, in vitro anticancer activity and oral bioavailability when compared to those of paclitaxel. The disulfide bond in these prodrugs can undergo sulfhydryl-assisted cleavage to release paclitaxel in vivo by a plausible mechanism as shown in the scheme.
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Authors
Machhindra Gund, Amit Khanna, Nauzer Dubash, Anagha Damre, Kishore S. Singh, Apparao Satyam,