| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586446 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A novel set of compounds containing a unique '1-(nitrooxy)ethyl ester' group act as true prodrugs of aspirin and exhibit excellent oral bioavailability, NO-release profile and gastric-sparing properties. The same properties are also shown by the corresponding NO-naproxen prodrugs. Additionally, NO-aspirin prodrug exhibits antithrombotic activity comparable to that of aspirin. Dn = D1, D2, D3 and so on; D1C(O)OH = aspirin; D2C(O)OH = naproxen; R = methyl, ethyl, n-propyl or n-butyl; SGF = simulated gastric fluid; SIF = simulated intestinal fluid, HP = human plasma.41
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Authors
Machhindra Gund, Parikshit Gaikwad, Namdev Borhade, Aslam Burhan, Dattatraya C. Desai, Ankur Sharma, Mini Dhiman, Mohan Patil, Javed Sheikh, Gajanan Thakre, Santhosh G. Tipparam, Somesh Sharma, Kumar V.S. Nemmani, Apparao Satyam,