| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586495 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Serotonin was linked by amidation to the carboxylic acid groups of a series of structurally diverse NSAIDs. The resulting NSAID-serotonin conjugates were tested in vitro for their ability to inhibit FAAH, TRPV1, and COX2. Ibuprofen-5-HT and Flurbiprofen-5-HT inhibited all three targets with approximately the same potency as N-arachidonoyl serotonin (AA-5-HT), while Fenoprofen-5-HT and Naproxen-5-HT showed activity as dual inhibitors of TRPV1 and COX2.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tyler M. Rose, Christopher A. Reilly, Cassandra E. Deering-Rice, Clinton Brewster, Chelsea Brewster,