Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10586511 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
This Letter describes the synthesis and biological evaluation of a number of functionalized bisimidazoles bearing annulated tricyclic motifs as potent inhibitors of HCV NS5A protein. Compound 4h, which contains a substituted tricyclic 6-6-6 xanthene, demonstrated broad genotypic spectrum, compelling potency, and good oral bioavailability with dose-dependent drug exposure level in multiple animal species.
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Physical Sciences and Engineering
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Organic Chemistry
Authors
Min Zhong, Eric Peng, Ningwu Huang, Qi Huang, Anja Huq, Meiyen Lau, Richard Colonno, Leping Li,