Article ID Journal Published Year Pages File Type
10586511 Bioorganic & Medicinal Chemistry Letters 2014 5 Pages PDF
Abstract
This Letter describes the synthesis and biological evaluation of a number of functionalized bisimidazoles bearing annulated tricyclic motifs as potent inhibitors of HCV NS5A protein. Compound 4h, which contains a substituted tricyclic 6-6-6 xanthene, demonstrated broad genotypic spectrum, compelling potency, and good oral bioavailability with dose-dependent drug exposure level in multiple animal species.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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