| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586535 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A novel phosphonooxymethyl prodrug with fasciolicidal activity has been synthesized. The prodrug showed a 50,000 fold increase in aqueous solubility in comparison to its precursor compound. The prodrug was evaluated in vitro and in vivo against Fasciola hepatica, demonstrating high fasciolicidal activity in vivo.88
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Authors
Miguel Flores-Ramos, Froylán Ibarra-Velarde, Alicia Hernández-Campos, Yolanda Vera-Montenegro, Helgi Jung-Cook, Germinal J. Cantó-Alarcón, Lauro Misael del Rivero, Rafael Castillo,