Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-aminopiperidine derivatives

Article ID	Journal	Published Year	Pages	File Type
10586750	Bioorganic & Medicinal Chemistry Letters	2014	4 Pages	PDF

Keywords

BOC Pd(dppf)Cl2 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl PyBroP PPh3 Xphos Pd2(dba)3 Pd(PPh3)4 U2OS tert-butyloxycarbonyl SAR CCR2 AcOH TFA DMAP CCL2 DCE DCM THF DMSO N,N-dimethylaminopyridine N,N-diisopropylethylamine Pd(OAc)2 Antagonist Palladium acetate Trifluoroacetic acid Acetic acid Tetrahydrofuran Tetrakis(triphenylphosphine)palladium(0)LDA Triphenylphosphine Dichloroethane Dichloromethane Dimethylsulfoxide structure–affinity relationships Molecular sieves Lithium diisopropylamide chemokine ligand 2 microwave Methanol MeOH knockout DIPEA Chemokine chemokine receptor 2

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Design and synthesis of novel small molecule CCR2 antagonists: Evaluation of 4-aminopiperidine derivatives

Authors

M. Vilums, A.J.M. Zweemer, S. Dekkers, Y. Askar, H. de Vries, J. Saunders, D. Stamos, J. Brussee, L.H. Heitman, A.P. IJzerman,