Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10586765 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Pseudomonas aeruginosa strains resistant towards all currently available antibiotics are increasingly encountered, raising the need for new anti-pseudomonal drugs. We therefore conducted a medium-throughput screen of a small-molecule collection resulting in the identification of the N-alkylated 3,6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol (MIC = 18.5 μg mLâ1). This compound, compound 1, is bacteriostatic towards a broad spectrum of Gram-positive and Gram-negative pathogens, including P. aeruginosa. Importantly, 1 also eradicates mature biofilms of P. aeruginosa. 1 displays no cytotoxicity against various human cell types, pointing to its potential for further development as a novel antibacterial drug.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Veerle Liebens, Evelien Gerits, Wouter J. Knapen, Toon Swings, Serge Beullens, Hans P. Steenackers, Stijn Robijns, Anna Lippell, Alex J. O'Neill, Matija Veber, Mirjam Fröhlich, Annika Krona, Maria Lövenklev, Romu Corbau, Arnaud Marchand,