Article ID Journal Published Year Pages File Type
10586927 Bioorganic & Medicinal Chemistry Letters 2014 7 Pages PDF
Abstract
The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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