| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586940 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
In our continuous efforts to identify and develop novel targeted cancer treatments, a new morpholino-thiazole scaffold active against PI3Kβ has been identified. This Letter reports the optimization of this compound class to develop PI3Kβ isoform-selective inhibitors with suitable pharmacological properties.
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Authors
Victor Certal, Frank Halley, Angela Virone-Oddos, Bruno Filoche-Rommé, Jean-Christophe Carry, Florence Gruss-Leleu, Luc Bertin, Houlfa Guizani, Fabienne Pilorge, Patrick Richepin, Andreas Karlsson, Véronique Charrier, Pierre-Yves Abecassis,