| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586980 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Abran Costales, Michelle Mathur, Savithri Ramurthy, Jiong Lan, Sharadha Subramanian, Rama Jain, Gordana Atallah, Lina Setti, Mika Lindvall, Brent A. Appleton, Elizabeth Ornelas, Paul Feucht, Bob Warne, Laura Doyle, Stephen E. Basham, Ida Aronchik,