| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10586986 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Cyclopentylamine 4 was identified as a potent dual NK1R antagonist-SERT inhibitor. This compound demonstrated significant oral activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.
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Authors
Yong-Jin Wu, Huan He, Qi Gao, Dedong Wu, Robert Bertekap, Ryan S. Westphal, Snjezana Lelas, Amy Newton, Tanya Wallace, Matthew Taber, Carl Davis, John E. Macor, Joanne Bronson,