Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10586991 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Thermal transformation of the (+)-catechin (1) with heating processing afforded a new oxidation product, gambiriin D (2), along with catechin [6â²-8]-catechin (3), and (+)-epicatechin (4). The structure of a new catechin dimer with C-C linkage was determined on the basis of spectroscopic data interpretation. The catechin dimers 2 and 3 exhibited significantly improved inhibitory activities against α-glucosidase, with IC50 values of 0.16 ± 0.2 and 0.14 ± 0.2 μM, respectively, when compared to parent (+)-catechin. Kinetic analysis showed that the two effective compounds 2 and 3 have noncompetitive modes of action.
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Authors
Taewan Kim, Hyo Jin Choi, Sung-Hwan Eom, Jaemin Lee, Tae Hoon Kim,