| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587065 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Novel small molecule HDM2 inhibitor, substituted piperidine, was identified. Initial SAR study indicated potential for several position optimizations. Additional potency enhancement was achieved by introducing a sidechain off the aromatic ring. DMPK study of one of the active compounds has shown a moderate oral PK and reasonable bioavailability.
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Authors
Yao Ma, Brian R. Lahue, Gerald W. Jr., Jeseca Brookes, Yaolin Wang,