| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10587088 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM. Compound 1m exhibited maximum potency being 5.87 fold more active at EC50 and 6.26 fold more active at EC90 than the standard drug pyrimethamine.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Singanan Ponnuchamy, Selvaraj Kanchithalaivan, Raju Ranjith Kumar, Mohamed Ashraf Ali, Tan Soo Choon,