Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10587103 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.
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Authors
Panoula Anastasopoulou, Georgia Kythreoti, Tilemachos Cosmidis, Constantina Pyrkotis, Victoria R. Nahmias, Dionisios Vourloumis,